This research brief examines neonatal and maternal hospital stays for Pennsylvania residents where a substance-related condition was present. Neonatal stays include newborns as well as hospitalizations for other neonates less than one year old. Maternal stays include those involving a delivery, as well as other pregnancy-related stays. This research brief looks at trends in hospital discharges across several federal fiscal years (FFY) of data. Each FFY spans the period from October 1 to September 30. The analysis includes neonatal and maternal stays occurring in Pennsylvania general acute care hospitals between FFYs 2000 and 2015.